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JAPANESE

Thyroid Hormone Action Indicator Transgenic Mouse

Proposal Number : 1163927       Provide technologies/know-how
Date Date of Registration : Jan 09, 2019
Date of Revision : Jan 09, 2019
Country / AreaCsongrad, Hungary 
Proposal Category 8802 Bio-medicine and therapeutics (vaccines, biological products, bio-diagnostics / pharmaceuticals, gene-diagnostics / therapeutics )
Target Country / Area All Countries / Areas

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Detail Description

Thyroid Hormone Action Indicator Transgenic Mouse

<< DESCRIPTION >>
A Hungarian academic research institute developed a Thyroid Hormone Action Indicator (THAI) Mouse, a transgenic mouse model to measure the authentic thyroid hormone signalling in a live animal.Thyroid hormone (TH) is a fundamental regulator of metabolism and cell proliferation and its level is subjected to tissue-specific regulation. This development is based on a thyroid hormone-dependent expression of a luciferase reporter protein. THAI represents the first mammalian model for tissue-specific assessment of TH action using an intact machinery of TH metabolism and signalling. THAI mouse also allows the assessment of TH action in live mammals for the first time using in vivo imaging facilitating time series studies and testing of different compounds/doses in the same animal. It was generated using a transposase-mediated approach that allowed the insertion of a single copy of the transgene into the genome that allow quantitative measurements and stable maintenance of the line without segregation of the transgenic cassette.

TECHNOLOGY ADVANTAGES:
- The TH action in the THAI mouse is determined by the fully endogenous set of regulators of thyroid hormone action including thyroid hormone receptors isoforms and their coregulators, the thyroid hormone activating and inactivating deiodinase enzymes and thyroid hormone transporters;
- It allows the detection of tissue-specific TH action in live animals,
- It can distinguish between thyroid hormone receptor isoform mediated effects.
THAI has been successfully used
a) to study the cold-induced regulation of TH action in the brown adipose tissue, an important target of obesity research;
b) to test the in vivo efficiency of a thyroid hormone isoform specific compound;
c) to study tissue hypothyroidism and
d) to asses thyroid hormone action in microdissected brain samples.

<< EXAMPLES OF ACTUAL APPLICATIONS >>
POTENTIAL APPLICATIONS AND POTENTIAL CUSTOMERS:
THAI mouse provides an excellent in vivo model for pharmaceutical companies aim to develop thyromimetic drugs for tissue-specific TH action or companies running exploratory studies for future drug development. Tissue- or TH receptor isoform specificity of new TH agonist/antagonist compounds could be tested with the help of the THAI mouse. These compounds could impact obesity and cholesterol level: that is a significant market.

Patent Status  
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