|Date||Date of Registration : Oct 27, 2011
Date of Revision : Oct 27, 2011
|Country / Area||Csongrad, Hungary|
|Proposal Category||8802 Bio-medicine and therapeutics (vaccines, biological products, bio-diagnostics / pharmaceuticals, gene-diagnostics / therapeutics )|
|Target Country / Area||All Countries / Areas|
*Attention: JETRO shall not take any responsibility for the contents provided by users. Please take note of the fact that JETRO leaves the exactness and reliability of the contents to users' judgment.
Use of kynurenic acid amide derivatives for the treatment of HD
<< DESCRIPTION >>
The therapeutic importance of kynurenic acid analogues is further increased by the fact, that if the broad-spectrum receptory effects of KYNA are retained, they are capable of widespread anti-excitotoxic activity.
KYNA can inhibit N-methyl-D-aspartic (NMDA) acid receptors at the strychnine-insensitive glycine binding sites.
And it can also reduce the release of glutamate by inhibiting the presynaptic alfa-7-nicotinic acetylcholine receptors.
Furthermore several KYNA amides showed selective inhibition of the NR2B subunit containing NMDA receptors, and NMDA receptors containing these subunits have special importance in glutamate-induced excitotoxicity.
Since glycine and polyamine site agents, NR2B subunit specific antagonists and ion channel blockers with lower affinity may come into consideration as NMDA receptor antagonists, as they exert acceptable side-effects, the KYNA amide analogues have a significantly improved side-effect profile compared to other antiglutamatergic agents.
This presents a clear therapeutic advantage for patients.
<< EXAMPLES OF ACTUAL APPLICATIONS >>
Potential areas of use. Treatment of Huntington's disease.
HungaryJan 09, 2019 RegistrationJan 09, 2019 Revision
Total Sum of CONTACT Received : 0
HungaryNov 19, 2018 RegistrationNov 19, 2018 Revision
Total Sum of CONTACT Received : 1
HungaryNov 15, 2018 RegistrationNov 16, 2018 Revision
Total Sum of CONTACT Received : 5
HungaryNov 08, 2018 RegistrationNov 08, 2018 Revision
Total Sum of CONTACT Received : 2
HungarySep 07, 2018 RegistrationSep 07, 2018 Revision
Total Sum of CONTACT Received : 4